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ii) increased AMPK also inhibits mitochondrial glycerol-3-phosphate dehydrogenase (mGPD), leading to an increase in cytosolic NADH, which both stimulates the conversion of pyruvate to lactate, and simultaneously decreases gluconeogenesis
Fourth, catabolic intermediatesbranched-chain -keto acids (BCKAs) and branched-chain acylcarnitines (BCACs)accumulate when BCKDH flux is impaired and exert independent pathological effects that are mechanistically distinct from those of BCAAs per se
Lilly had given investors a preview of the Nature Medicine research in December
Pavord S, Myers B, Robinson S, Allard S, Strong J, Oppenheimer C
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