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Dietary epigenetic modulators: unravelling the still-controversial benefits of mirnas in nutrition and disease

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At the index date in GLP-1 RA vs SGLT-2 inhibitor cohort, GLP-1 RA users were generally younger (median age 55 years [25-75 percentile: 45-65] vs 66 years [25-75 percentile: 57-74] more often female (59% vs 36%) and had a higher level of education compared with SGLT-2 inhibitor users (21% vs 15% were within ISCED level 6-8)

Accordingly, targeting the double-edged nature of lipid metabolic reprogramming has emerged as a major focus of current research

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