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Results Dual blockade of GDF8 and ActA during GLP-1 RA-induced weight loss in obese mice preserves lean mass while also increasing fat loss To test whether dual blockade of GDF8 and ActA could help attenuate loss of lean mass during GLP-1 RA-induced weight loss, we tested our antibody combination in diet-induced obese (DIO) mice during treatment with the GLP-1 RA semaglutide (approved by the US Food and Drug Administration as a therapeutic for obesity and diabetes with the brand names of Ozempic and Wegovy)

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GLP-1 receptor agonists stimulate insulin secretion from pancreatic beta cells in a glucose-dependent manner, meaning they promote insulin release only when blood glucose levels are elevated

Furthermore, rapid changes in body composition and fluid distribution during weight loss may temporarily affect muscle function