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Bone is living tissue that is constantly being broken down and rebuilt by opposing teams of cells, and that remodeling process requires energy, nutrients, and hormonal coordination

The Crude HR for MOF with GLP-1 RAs compared to DPP-4is was 0.89 [0.761.05]

Despite these recommendations, there is limited real-world data evaluating outcomes of GLP1-RAs specifically in patients with moderate to advanced CKD or ESRD

The albumin conjugation is designed to be resistant to retro-Michael addition, a common chemical failure mode that causes decoupling of the agonist from the carrier

Phase 2 trials published in the New England Journal of Medicine showed the 12 mg dose group losing 24.2% of body weight at 48 weeks