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In den enthaltenen Dosierungen sind keine hufigen Nebenwirkungen bekannt

A paradoxical effect

TNFRSF1A variants can result in TNF receptor-associated periodic syndrome (TRAPS), an autoinflammatory disease characterized by paroxysmal fever, pain (chest, abdomen, muscles), rash and outwards signs of inflammation (e.g., conjunctivitis, periorbital edema) (40, 41)

Maintz L, Novak N, Histamine and histamine intolerance, The American Journal of Clinical Nutrition, Volume 85, Issue 5, May 2007, Pages 11851196

Ultrastructural studies have revealed an increased number and size of compound melanosomes within basal keratinocytes