Orally administered semaglutide versus GLP-1 RAs in patients with type 2 diabetes previously receiving 12 oral antidiabetics: systematic review and network meta-analysis

A Comparative Review of the Safety and Efficacy of Bariatric Surgery Versus Glucagon-Like Peptide-1 Analogue Accessed on April 16, 2024, at National Library of Medicine Estimating and reporting treatment effects in clinical trials for weight management: using estimands to interpret effects of intercurrent events and missing data Accessed on April 16, 2024, at National Library of Medicine Weight Loss Outcomes Associated with Semaglutide Treatment for Patients with Overweight or Obesity Accessed on April 16, 2024, at Drugs.com Comparing Wegovy vs Zepbound Accessed on April 16, 2024, at Drugs.com How long until I lose weight on Wegovy? Accessed on April 16, 2024, at New England Journal of Medicine Once-Weekly Semaglutide in Adults with Overweight or Obesity Accessed on April 16, 2024, at Lilly Investors FDA Approves Lilly's Zepbound (tirzepatide) for Chronic Weight Management, a Powerful New Option for the Treatment of Obesity or Overweight with Weight-Related Medical Problems Accessed on April 16, 2024, at Continued Treatment with Tirzepatide for Maintenance of Weight Reduction in Adults with Obesity Semaglutide vs Tirzepatide for Weight Loss in Adults with Overweight or Obesity | Obesity | JAMA Internal Medicine | JAMA Network at Lilly's Zepbound (tirzepatide) superior to Wegovy (semaglutide) in head-to-head trial showing an average weight loss of 20.2% vs

Continue your metformin as normal You dont need to change your metformin dose or timing when starting Wegovy
Acute kidney failure due to dehydration has also been reported in other clinical trials amongst patients treated with Semaglutide
doi: 10.31662/jmaj.2022-0209