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A single-use vial of plain sterile water has no mechanism to control that risk beyond the initial seal which is exactly why it's treated as single-use

I know this sounds a bit gruesome, but one can find in the historical medical literature

A pharmacokinetic study in rats found that oral administration produced substantial plasma concentrations, with a maximum concentration of 2252 ng/mL and an elimination half-life of approximately 6.9 hours

(30) As a result, selection bias may have influenced the outcomes

[8][13] As seen previously with insulin analogues and oncology drugs, India typically sees a wave of 1030 generic/biosimilar entrants within 13 years of patent expiry, which rapidly pulls prices down