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However, these patients had multiple risk factors for b12 deficiency beyond semaglutide use, including previous gastric surgery that permanently alters stomach anatomy and reduces intrinsic factor production

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Data synthesis and analysis Summary odds ratios (ORs) were estimated for OH (whether a patient had OH or not while taking the medication or placebo) as a dichotomous outcome using fixed effects MantelHaenszel statistics

What the human evidence shows: weight, body composition, and performance Several randomized human trials and metaanalyses have reported modest but consistent reductions in body weight and fat mass with Lcarnitine supplementation

Poorly controlled hyperthyroidism poses greater risk