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Importantly, incubation with IsoK resulted in a 59% decrease in function compared with vehicle control (Figures 5c and d), with no change in Km (Figure 5e)

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10,11 Patients should be instructed to measure blood glucose frequently and be educated on proper hypoglycemia protocols

Behavioral therapy, such as cognitive behavioral therapy or motivational interviewing, may also be helpful in changing habits and promoting adherence to treatment