One current example of polypharmacology in the clinic is Eli Lillys investigational drug Retatrutide, which acts as a triple agonist against glucagon, GIP, and GLP-1 receptors (Figure 1), engendering even greater weight loss in clinical trials than approved blockbuster drugs Semaglutide (GLP1-R agonist) and Tirzepatide (dual GLP1-R/GIP agonist)
The resultant supernatant layer (serum) was aspirated, transferred into Eppendorf tubes, and stored at -80 C till the time of analysis
It is also worth noting, that Novo Nordisk on August 17th announced the acquisition of Bristol based Ziylo in an effort to develope glucose responsive insulin, which would reduce the risk of patients overdosing with insulin
Because the majority of diabetes patients have T2DM, prescribing practices and clinical guidelines consistently prioritize GLP-1 therapy for this group, ensuring that T2DM remains the leading indication driving revenue and market share within the global GLP-1 receptor agonist segment
Muiz, Andrea Rodrguez, Vivian Padn and Natalia Vega for technical support