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Indeed, removal of mSOD1 from either microglial cells or astrocytes in fALS mice prolonged the late progression of the disease [17, 40]

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In ATTAIN-2 , which specifically studied people with both obesity and type 2 diabetes (a group for whom weight loss is known to be harder), participants on the highest dose lost an average of 10.5% of body weight (about 23 lbs) over 72 weeks, while also reducing A1C by an average of 1.8%