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Importantly, combining mTORC1 inhibitors with imidazole ketone erastin (IKE), a bioavailable ferroptosis inducer, exhibited synergistic tumor-suppressing effects in patient-derived xenografts of lung cancer

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GPX4 inactivation but also promotes the formation of GSH-Fe complexes

Guo C, Huang T, Chen A, Chen X, Wang L, Shen F, Gu X

It is especially common in older individuals, occurring in more than 20% of the elderly population (Vitamin B12 (cobalamin) deficiency in elderly patients)