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For the most part, the bulk of anti-obesity medication use comes from those first two medications which are from a category of drug called GLP1 analogues

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Tier 2 (BMI 30 or higher) requires heart failure with preserved ejection fraction, uncontrolled hypertension on two or more medications, or chronic kidney disease stage 3a or higher

As GLP-1 receptor expression positively correlates with serum androgen levels, the hyperandrogenic state seen in obese women may heighten their responsiveness to GLP1-RAs, they wrote