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Dosing Protocol A suggested daily subcutaneous titration approach based on common reference doses

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Pharmacological inhibition of CSF1R has therefore emerged as a promising strategy to modulate TAM function and enhance immunotherapy efficacy

Additionally, pathway enrichment analysis further revealed that these alterations corresponded to disruptions in key metabolic routes, including the glucose-alanine cycle, glucose metabolism, beta-oxidation of very long-chain fatty acids, glutathione metabolism, transfer of acetyl groups into mitochondria, and the degradation pathways of branched-chain aminoacids (BCAA) (Figure S3)