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We next performed coimmunoprecipitation assays using MIN6-K8 mouse insulinoma cells (26) overexpressing Barr1 and a FLAG-tagged version of Epac2

Activation of c-Jun-N-terminal kinase is required for apoptosis triggered by glutathione disulfide in neuroblastoma cells

While the insulin receptor activates mainly the IP3k-PKB-ERK signaling cascade [88, 101], the GLP-1 and GIP receptors activate mainly the cAMP-PKA-CREB growth-factor signaling cascade in target cells (Fig

Three classes of peptides target the neuroendocrine mechanisms of vitality: kisspeptin acts upstream of the HPG axis, GHRH analogs stimulate pulsatile GH, and GHRP secretagogues activate ghrelin receptors to support somatotropic homeostasis