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Pooling across the field, a 2025 meta-analysis of seven randomized controlled trials, covering 456 participants, reported a standardized mean difference of -0.72 for wrinkle reduction, though the analysis noted high heterogeneity between studies and that roughly 40% of trials had industry funding both factors that warrant caution in interpreting the pooled effect size

I dont think [GLP-1s] are inherently good or bad, but for people with eating disorder vulnerability, context, screening and monitoring matter so much, Davis said

The average treatment duration of these studies which compared weight loss drugs with either placebo or behavioral weight management programs was 39 weeks, while the average follow-up was 32 weeks

Always consult with your healthcare provider for medical advice to avoid unintended side effects

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