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Novel immunotherapy combinations with chemotherapy or targeted agents/tyrosine kinase inhibitors are being assessed and developed for multiple indications that will add another layer of complexity to adverse events and their management

However, when the extent of hepatocyte damage exceeds their capacity for self-replication, other liver cells are activated to undergo dedifferentiation or transdifferentiation, thereby compensating for the lost tissue

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Early studies used confirmatory surgical excision immediately after non-surgical ablations, employing dual staining methods to enhance pathological accuracy