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SGLT2 inhibitors are postulated to induce selective volume contraction.24 Thus, there is a selective reduction of interstitial fluid in contrast to traditional diuretics.24 Therefore, intravascular volume depletion and fluid retention by the reninangiotensinaldosterone system (RAAS) in the long run are limited.25 SGLT2 inhibitors also inhibit myocardial Na+/H+ exchanger (NHE) 1,5 which has been hypothesised to attenuate cardiac hypertrophy and HF development.26 Natriuresis is reported to improve left ventricular (LV) preload conditions, which could be potentiated by additional NHE-3 inhibition at the proximal tubules
Some unanswered questions remain, though, about how these drugs would affect addiction
It binds to melanocortin receptors (MC1R, MC3R, MC4R) in the hypothalamus an area of the brain involved in regulating sexual behavior, arousal, and motivation
Pfingstgraf, I
[DOI] [PubMed] [Google Scholar] [29].Petersen RC
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