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Published Phase 2 effect sizes most prominently the ~24 percent mean body weight reduction at the 12 mg dose tier in the obesity Phase 2 (PMID 37366315) exceed those reported for dual or single agonists at comparable durations, an outcome that researchers attribute to the additional glucagon-arm contribution to body-composition and energy-expenditure pathways

Traditional approaches just werent working for me

To try to overcome this, she teamed up with Walenskys lab, which had previously shown that stapling these small peptides can make them more stable and help them get into cells

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your provider's clinical judgment, your medical history, and your early response are equally important in determining your dose