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The results of the ACHIEVE-1 study, which were presented at the ADA congress in Chicago and simultaneously published in the New England Journal of Medicine, showed that once-daily orforglipron achieved significant improvements in haemoglobin A1c a market for blood glucose control at all three doses tested compared to placebo at 40 weeks

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M.LokshinaI.HigashikuboR.EvansS.et al (2019)

While in DCs, the xCT was highly expressed, its role is to mediate the extracellular uptake of cystine and intracellular release of glutamate