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"However, because of the small number of suicidal thoughts or actions observed in both people using GLP-1 RAs and in the comparative control groups, we cannot definitively rule out that a small risk may exist

For most people, starting with 1,000 mg/day and gradually increasing is the safest approach

For patients evaluating treatment options, understanding these distinctionsalongside biomarker context and individual genetic factorscan support more personalized discussions with healthcare providers

Gastrointestinal adverse events were more commonly observed in patients receiving resmetirom, but diarrhea was self-limited and did not promote drug withdrawal