Effects of once-weekly semaglutide vs once-daily canagliflozin on body composition in type 2 diabetes: a substudy of the SUSTAIN 8 randomised controlled clinical trial
It is taken once daily and comes in 3 mg, 7 mg, and 14 mg doses
Semaglutide is a GLP-1 receptor agonist licensed in the UK exclusively for type 2 diabetes mellitus treatment Weight loss from Ozempic can disrupt the hypothalamic-pituitary-ovarian axis, affecting oestrogen levels and menstrual regularity Women with PCOS may experience restored ovulatory cycles due to weight reduction, whilst others may develop temporary amenorrhoea Menstrual cycle changes are not listed as direct adverse effects in the MHRA-approved Summary of Product Characteristics Women should contact their GP for heavy bleeding, postcoital bleeding, amenorrhoea exceeding three months, or severe pelvic pain Effective contraception is essential as fertility may unexpectedly return with weight loss and metabolic improvement Table of Contents Does Ozempic Affect Your Menstrual Cycle
Initial study results show that people lose a larger percentage of weight as much as 30% of their body weight when they take retatrutide compared with placebo
Statistics Statistical analysis was performed using SPSS 26.0 (SPSS Inc, Chicago, IL, USA)
