While B12 is water-soluble with no established upper safe limit (according to NHS and EFSA guidance), this does not preclude the possibility of adverse reactions, particularly from injectable forms
NIH Office of Dietary Supplements Vitamin B12 Health Professional Fact Sheet: link MedlinePlus Cyanocobalamin injection: link Mayo Clinic Cyanocobalamin (intramuscular route): link IAPAM MIC Injections: link Fastic Do Vitamin B12, Lipo, and MIC Injections Actually Work for Weight Loss?: link FDA Using Fat-Dissolving Injections That Are Not FDA Approved Can Be Harmful: link Jacobson Cosmetic Surgery SlimShots (MIC/B12): link Eden B12 MIC Shots for Weight Loss: Cost & Reviews: link Journal of Clinical Endocrinology & Metabolism Inositol for PCOS: Systematic Review and Meta-analysis (2024): link
not primarily appetite-driven (OUP Academic) Expected weight loss (this is where many people get misled) In major obesity trials: Semaglutide 2.4 mg weekly: ~14.9% mean weight loss at 68 weeks (STEP-1) (PubMed) Tirzepatide: ~15.0% to ~20.9% mean weight loss at 72 weeks , dose-dependent (SURMOUNT-1) (PubMed) AOD-9604s best-known human signal is kilograms, not double-digit percentages , and later studies did not sustain a strong obesity-drug profile
Mar 22, [[cited 2013 Apr 4]]
Catalytic properties of the purified rat hepatic cytosolic cholesteryl ester hydrolase
