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Out of these, 803 participants who reached the semaglutide maintenance dose were randomized to 48 weeks of continued subcutaneous semaglutide or switched to placebo, both with lifestyle intervention

In some cases, autonomic effects such as increased peripheral vasoconstriction may make the hands and feet feel colder even without a major change in core body temperature

Bottom Line Semaglutide is not a blood pressure medication, but research suggests it may contribute to meaningful reductions in blood pressure as a result of weight loss and improved cardiometabolic health

If you're considering semaglutide as a part of your metabolic health journey, it's crucial to have an open and honest conversation with your healthcare provider

Store reconstituted solution at 28C and use within 28 days