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[DOI] [PMC free article] [PubMed] [Google Scholar] 14.Xie Y, Ramachandran A, Breckenridge DG, Liles JT, Lebofsky M, Farhood A, et al

Utilization of PBPK Modeling Approaches to Assess DDIs Caused by Mechanisms of Actions Evaluating the mechanism of action (eg, delayed gastric emptying, reduced fat mass and inflammation, and changes in GFR)-mediated DDIs of GLP-1 RAs and a dual GLP-1/GIP RA is often challenging to control for and clinical studies are costly

Downstream effector proteins targeting cellular processes other than actin dynamics may be important in this aspect

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