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The first 1 mg engages more of the GIP receptor than the next 11 mg combined. GLP-1 appetite suppression continues to rise, but the added benefit narrows in the higher bands while side effects keep increasing

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It would be interesting to know if the people experiencing the most weight loss, independent of which medication was taken, had the least likelihood of developing depression. It is possible that the medications have a direct impact on mood as well as an indirect impact on mood through causing weight loss, Creel added