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That kind of adjustment is one of the clearest, most practical reasons physician-supervised treatment tends to outperform unsupervised prescribing on both comfort and results

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Clinical trials for tirzepatide typically lasted 40-72 weeks, which may be insufficient to detect cancers with long latency periods

A variety of analyses (Table 2: scenario sets 1724) explored alternative assumptions about HbA1c thresholds triggering treatment intensification to basal and basal + bolus insulin regimens, as well as the extent to which interventional drugs were continued alongside insulin regimens prior to patient death