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1 Introduction According to the International Diabetes Federation, the global population with diabetes reached 537 million by 2021, with 90% of cases attributed to type 2 diabetes (T2DM) ( In recent years, glucagon-like peptide-1 receptor agonists (GLP-1RAs) have gained attention not only for their role in glycemic control in T2DM but also for their potential in weight management

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FIGURE 1 Anthropometric and laboratory assessments The clinical data were collected by a trained interviewer through a standard questionnaire that consisted of age, duration of diabetes, history of diseases that could interfere with bowel cleaning quality, current or prior use of drugs, smoking, drinking, and gastrointestinal symptoms

Table 2 provides an overview of locally acting (within the GI tract) and systemic oral peptide therapeutics that have been approved by the US Food and Drug Administration