More severe issues of GLP-1s can include: Pancreatitis, or severe abdominal pain radiating to the back, and vomiting Bowel obstruction, which consists of severe abdominal pain, vomiting, bloating, and constipation Severe gastroparesis, a chronic condition characterized by delayed stomach emptying without a physical blockage Identifying the Signs of Pancreatitis and Obstruction These can seem similar to many of the common side effects, so its important to know the difference
Examples include: Semaglutide (Ozempic and Wegovy) Liraglutide (Saxenda and Victoza) Dulaglutide (Trulicity) These drugs: Help the body release insulin, but when blood sugar levels go up Lower glucagon levels to stop extra glucose from being made Slow down how fast the stomach empties so you feel full longer Curb hunger, which makes it easier to eat fewer calories When used with supervision, GLP-1 drugs like semaglutide may help people lose weight and manage metabolic health
Li X, Liu Q, Pan Y, Chen S, Zhao Y, Hu Y (2023) New insights into the role of dietary triglyceride absorption in obesity and metabolic diseases
Ozempic and Wegovy last in the body much longer than natural GLP-1, as they resist breakdown by DPP-4 more effectively
For some patients near goal weight, an oral maintenance option may eventually become attractive