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[12] [13] Semaglutide works primarily by enhancing insulin secretion in response to elevated glucose levels, suppressing glucagon release, slowing gastric emptying, and reducing appetite through central nervous system pathways

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RYBELSUS and OZEMPIC tablets are contraindicated in patients with a prior serious hypersensitivity reaction to semaglutide or to any of the excipients in RYBELSUS or OZEMPIC tablets [see Adverse Reactions (6.2)]

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Why protein and strength training are important during weight loss To optimize body composition during weight loss, it is important to combine the treatment with an adequate protein intake and regular strength training