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Evidence to date is primarily derived from preclinical and animal models, with emerging case series data

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Collagen is "hygroscopic," which means it attracts and holds water molecules from the surrounding environment

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CAMA1 and EFM-19 cells display differential sensitivity to single agent RSL3 and the RSL3 plus giredestrant combination in DMSO pre-treated cells, but both were sensitized to RSL3 following giredestrant pre-treatment