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An intervention using an anti-IL-1Ra antibody in M.tb -infected B6.Sst1 s mice, designed to block IL-1Ra and restore IL-1 signaling, resulted in decreased bacterial burden in the lungs, maintained body weight, and reduced lung lesions in mice [56], suggesting that IL-1Ra might be a promising target for HDT during M.tb infection

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Am J Gastroenterol 2016

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