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Uncontrolled diabetes could lead to oxidative stress, inflammation signaling activation, and the release of pro-inflammatory cytokines

These benefits must be balanced against class-specific safety concerns, especially the increased risk of DKA with SGLT2-based therapies

These treatments are particularly beneficial for those with a body mass index (BMI) of 30 or higher or individuals with a BMI of 27 or higher with comorbidities such as type 2 diabetes, high blood pressure, or high cholesterol

This combined interpretation helps distinguish a primary disturbance in glutathione metabolism from a downstream response to broader cellular stress

doi: 10.1016/j.freeradbiomed.2007.06.014