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That observation has implications for conversion accuracy: the precision difference between underdosing at 4.5mg versus hitting 5mg exactly may matter more at lower doses than the difference between 14mg and 15mg at higher doses
For patients considering a GLP-1 program, that track record matters
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Additionally, the proximity of the rectum to the urethra (particularly in women) means that prolonged constipation increases the bacterial load near the urinary opening
References: Falutz, J., Allas, S., Blot, K., Potvin, D., Kotler, D., Somero, M., Berger, D., Brown, S., Richmond, G., Fessel, J., Turner, R., & Grinspoon, S
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