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Further investigation showed that CPs first reduce the level of skin oxidation, inhibit the expression of the key transcription factor AP-1 (c-Jun and c-Fos), then activate the TGF-/Smad signaling pathway to promote collagen synthesis, inhibit the expression of MMP-1/3 to inhibit collagen degradation, and inhibit skin inflammation to alleviate skin aging in mice

These results establish the IGF axis as a key regulator of tumor immune escape and support the rationale for combination strategies targeting IGF-1R signaling with immune checkpoint blockade in immunotherapy-resistant prostate cancer

(3) For the other 10-20%, we work with several other treatment avenues to minimize any symptoms of chronic Lyme disease

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L., Spear, B