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Both of these conditions are a result of the interaction of multiple genetic factors and environment, involving multiple genes with small interactive and additive effects

The majority of the annotated genomes, 137 of the 168, share this same gene neighborhood for all three genes ( Table 1 and Supplementary Table 4 )

When examining the individual components of the primary endpoint, we observed closely concordant results for myocardial infarction and stroke but divergent results for all-cause mortality, suggestive of residual confounding

doi: 10.1016/j.apsb.2014.12.003

Devarbhavi H, Asrani SK, Arab JP, Nartey YA, Pose E, Kamath PS