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Furthermore, ablating the IGF-IR gene specifically in growth plate chondrocytes in mice increases their expression of PTHrP, but not PTH1R (32)

Insulin-like growth factor-I is essential for embryonic bone development

IGF-1 LR3 costs $150$300 per vial in most research settings

This compound produces minimal appetite stimulation

Thus, it is possible that the combination of low GH and normal IGF-I serves as a physiological mechanism aimed at preserving the GH/IGF-I anabolic effects and minimizing the insulin-antagonistic effects of GH without compromising the positive IGF-I metabolic effects