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The NOS2 gene is located on chromosome 17q11.2 and is composed of 27 exons that encode a protein of 1153 amino acids

Interestingly, certain gallic acid derivatives appear even more effective: metabolites such as propyl gallate, methyl gallate, and other alkyl gallate esters exhibited stronger neuroprotective effects than gallic acid in some PD models (9)

Kynurenine is subsequently converted to NAD + in a chain of reactions with the rate-limiting step by quinolinic phosphoribosyltransferase (QPRT), which converts quinolinic acid into nicotinic acid mononucleotide (NAMN) 26 , finally entering the PreissHandler pathway