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doi:10.1590/s0004-28032014000200014

Hu Y, Correa AM, Hoque A, Guan B, Ye F, Huang J, Swisher SG , Wu TT, Ajani JA, Xu XC

This has important clinical implications, as the majority of ER(+) breast cancer patients are currently treated with breast-conserving surgery (lumpectomy) plus radiation therapy and hormonal therapy with an anti-estrogen

In 2012, RAS -mutated tumor cell death by overwhelming lipid peroxidation that produced lipid reactive oxygen species (ROS, a class of highly reactive chemical molecules formed from the electron receptivity of O 2 )

However, their clinical application remains challenging due to metabolic heterogeneity, compensatory pathway activation, and immunosuppressive effects