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Conclusion FOXO4-DRI remains one of the most advanced and widely discussed senolytic peptides in longevity science and regenerative research

42 The mechanisms of these complex effects are still being elucidated, and it is unclear whether there is a direct effect via GLP-1 receptors in bone cells or indirect effects mediated through the gut

Yes, GLP-1 medications and testosterone replacement have no direct contraindication and are frequently used together

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Thus, the SAG administration showed anti-inflammatory effects decreasing pro-inflammatory cytokines TNF-, IL-6, MCP-1 and IL-1 in both serum and liver, and suppressing the TLR4/NFkB pathway