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In PD, a ketogenic diet trial (very high fat, low carbohydrate) is underway, hypothesizing shifts in the microbiome/metabolome (elevated ketones and possibly Akkermansia ) with potential motor benefits [236]

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This rapid response makes injections particularly valuable for people experiencing acute deficiency symptoms

Method Literature search strategy Google Scholar and PubMed were searched on various dates between December 2016 and March 2017, ending on 15th March 2017 using the following terms, and variants thereof, and all articles discovered were considered for inclusion: (paracetamol OR acetaminophen hepatotoxicity) AND genetic differences/polymorphisms OR children/neonates/young people/paediatric OR older people/elderly/geriatric OR nutritional state/malnutrition OR body weight/low body weight OR alcohol/alcohol-dependence OR drug interactions/potentiation OR liver disease/chronic liver disease/liver failure

10.1046/j.1365-4362.1999.00832.x [DOI] [PubMed] [Google Scholar] Braddock M