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Retatrutide is used in this context as a controllable perturbation tool, enabling laboratories to compare receptor class specific signatures and downstream response patterns under matched assay conditions

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doi: 10.1111/dom.12591 18 ZhaoZTangYHuYZhuHChenXZhaoB

MT-2 is a melanocortin receptor agonist with activity across multiple receptor subtypes, which differentiates it from more selective compounds

In addition to its effect on glucose homeostasis, glucagon has lipolytic and thermogenic actions in liver and adipose tissue which contribute to its weight-lowering effects [20]