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The hair shaft remains attached during telogen

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Experimental investigations show that senescent cells typically exhibit permanent cell cycle arrest mediated by p53/p21 signaling, creating a unique cellular state that depends on specific survival mechanisms for viability

It is suggested that dysfunction between A production and clearance causes damaging accumulations of cellular A, coupled with hyperphosphorylation of neuronal tau protein resulting in neurofibrillary tangle formation [10,11])