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Metformin has shown potential cardiovascular benefits in observational studies, while tirzepatide has demonstrated improvements in blood pressure and markers of cardiovascular risk in clinical trials

The semaglutide dosage calculator helps with precise measurements for those currently on semaglutide who are considering the switch

Want to learn more about GLP-1s prescribed as a part of the Calibrate program

If you are new to GLP-1 medications, reading our getting started with peptides guide and the common peptide mistakes guide will prepare you for productive conversations with any prescriber

Clinical data suggest Tirzepatide can produce even greater weight loss and HbA1c reductions than some GLP-1only options, although the best choice depends on your health profile, goals, and response