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They inhibit reactive oxygen species (ROS) formation and reduce endothelial dysfunction by upregulating nitric oxide production

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Additional risk factors include advancing age (due to reduced gastric acid production), excessive alcohol consumption (impairing absorption and storage), and rare genetic disorders affecting B12 transport or metabolism

This indicates that colonic inflammation was decreased by the activation of the aryl hydrocarbon receptor by Trp metabolites, as has previously been described for Bifidobacteria and other bacterial species [62-65]

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