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MMWR Morb Mortal Wkly Rep 72(1):16 Salguero MV, Arosemena M, Pollin T, Greeley SAW, Naylor RN, Letourneau-Freiberg L et al (2023) Monogenic forms of diabetes
The glucagon receptor component increases energy expenditure through thermogenesis, promotes hepatic fat oxidation (your liver burns more fat), and stimulates lipolysis (fat cells release their stored triglycerides for use as fuel)
Actionable Next Steps for Researchers: Prioritize Individual Research: Focus on thoroughly understanding each peptide (MOTS-c and Retatrutide) independently before considering combinations
It appears that the effects of gut permeability on immune activation and intestinal inflammation may vary, depending on the extent of mucosal barrier deregulation, and the context in which this occurs
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