The schedule mirrors the clinical-trial protocols that drove substantial weight loss around 20% of body weight over 72 weeks on the 15 mg dose [2] while holding gastrointestinal effects down through gradual escalation [1] [4]
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The rationale: early-phase neuroplasticity benefits from sustained HGF/c-Met signaling, but once synaptic remodeling is initiated, daily pulses are sufficient to maintain the effect
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