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Among these, 7 key targets (HSP90AA1, CASP3, KRAS, ERBB2, BCL2L1, GRB2, and SHC1) were up-regulated in BRCA, and the remaining 5 key targets were down-regulated

Those interested in peptide cycling strategies will recognize this pattern of therapeutic windows followed by consolidation periods

Apoptosis Int J Programmed Cell Death (2019) 24(11-12):892904

In some of such embodiments, a low viscosity otic formulation or device is administered in combination with an external otic intervention, e.g., a surgical procedure including but not limited to middle ear surgery, inner ear surgery, typanostomy, cochleostomy, labyrinthotomy, mastoidectomy, stapedectomy, stapedotomy, endolymphatic sacculotomy, or the like