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Selenium and selenoproteins: mechanisms, health functions, and emerging applications

Cell activation leads to the liberation of arachidonic acid from membrane phospholipids, and 5-LO converts arachidonate to LTA4, with 5-LO activating protein as a cofactor

4.2 Allergic asthma and allergic rhinitis An in vitro model of allergic airway inflammation, BEAS-2B human bronchial epithelial cells, were pre-treated with BBR (1 M) and activated, resulting in significant inhibition of IL-6 and CC motif chemokine ligand (CCL)-11 secretion, possibly through suppression of STAT6 signaling, without affecting cell viability [53]

Dai X, Ruan J, Guo Y, Sun Z, Liu J, Bao X, Zhang H, Li Q, Ye C, Wang X