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With the advance of combination therapy, the combination of targeted IGFs and other technologies for the treatment of tumors has shown advantages, which not only increase the efficacy but also effectively prevent the occurrence of drug resistance

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This shortening is a well-known biomarker of aging and is associated with increased risks of cancer, cardiovascular disease, neurodegeneration, and metabolic disorders Blackburn et al., Nature , 2006

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Its sequence includes multiple proline residues, which contribute to a specific helical structure